Growth Differentiation Factor-15 (GDF-15) is a Biological Marker in Heart Failure

Heart failure is an important medical, social and economic problem around the world. In recent years, a number of diagnostic prognostic biological markers blood in cardiovascular diseases have been studied. Identification new markers, analysis their pathophysiological aspects changes concentration under influence various treatment options, allow us to understand many pathogenetic features development course heart failure. decades, natriuretic peptides introduced into clinical practice, which are widely used as reliable for assessment. Growth differentiation factor-15 cytokine belonging family transforming growth factors, activity significantly increased stress inflammation. patients with chronic failure, this marker associated risk overall mortality adverse events; preserved left ventricular ejection fraction, use showed significance. Data from Framingham Study that was only multivariate statistically significant association all events. Eight studies overexpression It shown acute not inferior brain peptide precursor. To confirm value it necessary conduct extensive prospective randomized trials.